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Aktualisiert am: Sonntag APRIL 30 2017

Neue Hepatitis Daten betonen die Notwendigkeit von dringender globaler Antwort

Inhalt von: Weltgesundheitsorganisation

21 April 2017 | Geneva, Amsterdam -New WHO data reveal that an estimated 325 million people worldwide are living with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

Die WHO Global hepatitis report, 2017 indicates that the large majority of these people lack access to life-saving testing and treatment. As a result, millions of people are at risk of a slow progression to chronic liver disease, cancer, and death.

"Viral hepatitis is now recognized as a major public health challenge that requires an urgent response," said Dr Margaret Chan, WHO Director-General. "Vaccines and medicines to tackle hepatitis exist, and WHO is committed to helping ensure these tools reach all those who need them."

Increasing mortality, new infections

Viral hepatitis caused 1.34 million deaths in 2015, a number comparable to deaths caused by tuberculosis and HIV. But while mortality from tuberculosis and HIV has been declining, deaths from hepatitis are on the increase.

Approximately 1.75 million people were newly infected with HCV in 2015, bringing the global total of people living with hepatitis C to 71 million.

Although overall deaths from hepatitis are increasing, new infections of HBV are falling, thanks to increased coverage of HBV vaccination among children. Globally, 84% of children born in 2015 received the 3 recommended doses of hepatitis B vaccine. Between the pre-vaccine era (which, according to the year of introduction can range from the 1980s to the early 2000s) and 2015, the proportion of children under 5 years of age with new infections fell from 4.7% to 1.3%. However, an estimated 257 million people, mostly adults born before the introduction of the HBV vaccine, were living with chronic hepatitis B infection in 2015.

Epidemics in regions and "hotspots"

Hepatitis B levels vary widely across WHO regions with the WHO African Region and WHO Western Pacific Region sharing the greatest burden.

  • WHO Western Pacific Region: 6.2% of population (115 million people)
  • WHO African Region: 6.1% of population (60 million people)
  • WHO Eastern Mediterranean Region: 3.3% of population (21 million people)
  • WHO Südostasien Region: 2% der Bevölkerung (39 Millionen Menschen)
  • WHO-Region Europa: 1.6% der Bevölkerung (15 Millionen Menschen)
  • WHO Region Nord- und Südamerika: 0.7% der Bevölkerung (7 Millionen Menschen)

Heute unsichere Injektionen in der Gesundheitsfürsorge und der injizierende Drogenkonsum gelten als die häufigsten Routen von HCV-Übertragungen sein. HCV-Prävalenz von WHO-Region ist:

  • WHO Eastern Mediterranean Region: 2.3% of population (15 million people)
  • WHO-Region Europa: 1.5% der Bevölkerung (14 Millionen Menschen)
  • WHO African Region: 1% of population (11 million people)
  • WHO Region Nord- und Südamerika: 1% der Bevölkerung (7 Millionen Menschen)
  • WHO Western Pacific Region: 1% of population (14 million people)
  • WHO Südostasien Region: 0.5% der Bevölkerung (10 Millionen Menschen)

Die Behandlung Zugang niedrig

Derzeit gibt es keinen Impfstoff gegen HCV und Zugang zur Behandlung von HBV und HCV ist nach wie vor gering.

WHO Global Health Sektor Strategie auf Virushepatitis Ziel 90% zu testen und 80% der Menschen mit HBV und HCV durch 2030 zu behandeln.

Der Bericht stellt fest, dass nur 9% aller HBV-Infektionen und 20% aller HCV-Infektionen in 2015 diagnostiziert wurde. Ein noch kleinerer Anteil - 8% der Patienten mit HBV-Infektion diagnostiziert (1.7 Millionen Menschen) waren auf der Behandlung und nur 7% der Patienten mit HCV-Infektion diagnostiziert (1.1 Millionen Menschen) hatte kurative Behandlung während dieses Jahres gestartet.

HBV-Infektion erfordert lebenslange Behandlung und WHO empfiehlt derzeit die Tenofovir Medizin, bereits weit verbreitet in der HIV-Behandlung eingesetzt. Hepatitis C kann innerhalb einer relativ kurzen Zeit unter Verwendung der hochwirksame direkt wirkenden Virostatika (DAAs) ausgehärtet werden.

"We are still at an early stage of the viral hepatitis response, but the way forward looks promising," said Dr Gottfried Hirnschall, Director of WHO's Department of HIV and the Global Hepatitis Programme. "More countries are making hepatitis services available for people in need – a diagnostic test costs less than US$ 1 and the cure for hepatitis C can be below US$ 200. But the data clearly highlight the urgency with which we must address the remaining gaps in testing and treatment."

Country progress

WHO Global hepatitis report, 2017 demonstrates that despite challenges, some countries are taking successful steps to scale-up hepatitis services.

China achieved high coverage (96%) for the timely birth dose of HBV vaccines, and reached the hepatitis B control goal of less than 1% prevalence in children under the age of 5 in 2015. Mongolia improved uptake of hepatitis treatment by including HBV and HCV medicines in its National Health Insurance scheme, which covers 98% of its population. In Egypt, generic competition has reduced the price of a 3-month cure for hepatitis C, from US$ 900 in 2015, to less than US$ 200 in 2016. Today in Pakistan, the same course costs as little as US$ 100.

Improving access to hepatitis C cure received a boost at the end of March 2017, when WHO prequalified the generic active pharmaceutical ingredient of sofosbuvir. This step will enable more countries to produce affordable hepatitis medicines.

Baseline for elimination

WHO Global hepatitis report, 2017 aims to provide a starting point for hepatitis elimination by indicating baseline statistics on HBV and HCV infections, including mortality, and coverage levels of key interventions. Hepatitis B and C – the 2 main types out of 5 different hepatitis infections – are responsible for 96% of overall hepatitis mortality.

Hinweise für die Redaktion

World Immunization Week (24–30 April): WHO recommends the use of vaccines against 26 diseases, which include 3 vaccine-preventable types of viral hepatitis (A,B and E) out of 5 types of viral hepatitis (A,B,C,D,E).

World Hepatitis Day 2017 and World Hepatitis Summit 2017: WHO and partners will organize 2 high-profile global initiatives to advocate for an urgent response to viral hepatitis. World Hepatitis Day 2017 will be commemorated on 28 July under the theme “Eliminate hepatitis”. The World Hepatitis Summit 2017, the principal convention of the global hepatitis community, is being co-organized by WHO, the Government of Brazil and the World Hepatitis Alliance. It will be held on 1–3 November 2017 in São Paulo, Brazil.

Ansprechpartner für die Medien

Tunga (Oyuntungalag) Namjilsuren
Information Manager
WHO Abteilung für HIV, Hepatitis Globale Programm
Mobil: + 41 79 203 3176
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Christian Lindmeier
WHO Sprecher
WHO Department of Communications
Telefon: + 41 22 791 1948
Mobil: + 41 795 006 552
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